Tuscumbia Railway Depot, 204 West 5th St., Tuscumbia, AL 35674. This 1888 restored passenger depot was utilized by both the Memphis and Charleston and Southern Railway companies. In it’s early years, the depot was used often by Helen Keller and her teacher, Annie Sullivan. Today it is a museum dedicated to rail memorabilia. A Keller family carriage occupies one room of the museum. Tuscumbia boasts the first railroad west of the Appalachian Mountains. Admission. (256) 389-1357. www.tuscumbiarailway.com. Open by appointment.